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      肝纖維化及脂肪肝定量檢測技術簡介
      字號字體變小字體變大發布日期:  2017-07-20  

      肝纖維化、脂肪肝的發病率如何?

      肝纖維化是所有肝炎類疾病向肝硬化、肝癌發展的中間階段,在此階段,通過中醫藥的治療可以逆轉。若不及時治療,25%~40%的肝纖維化患者最終將進展為肝硬化甚至肝癌,此時已無法逆轉。截至2010年底,我國非酒精性脂肪性肝病發病率約15%左右,非酒精性脂肪性肝炎患者10~15年內肝硬化發生率高達15%~25%。截止2011年,我國酒精性脂肪性肝病患者人數在5000萬左右,如不及時治療,60%的酒精肝患者最終將轉化為肝硬化甚至肝癌。

      過去如何檢查肝纖維化、脂肪肝?

      肝穿刺活檢被視為評價肝纖維化程度的“金標準”,但其為有創性檢查,且無法動態評估療效,其肝組織標本取樣誤差及標本較小易導致肝纖維化準確性不足及肝硬化漏診,因而應用受到限制。

      抽血檢測“肝纖四項”也是檢測肝纖維化的一種方法,但其敏感性和特異性較低,易受到肝功能異常的影響。
      彩超、CT是既往診斷肝硬化及脂肪肝常用的檢查方法,然而兩者僅在肝纖維化發展為肝硬化時才能作出診斷,無法早期診斷及評估肝纖維化的程度。彩超、CT對脂肪肝只能判斷“輕、中、重度”,無法精確定量脂肪肝的程度,且彩超僅在肝脂肪變>30%時,才能檢查出脂肪肝,不能診斷肝脂肪變在11%~34%的脂肪肝患者。

      現在如何檢查肝纖維化、脂肪肝? 

      可通過“肝纖維化及脂肪肝定量檢測技術”對肝纖維化、脂肪肝的程度進行定量分級。該項目通過FibroScan機器檢測完成。FibroScan是法國Echosens公司研發生產的全球獨家擁有肝臟彈性測量技術和肝臟脂肪變性定量診斷技術的肝臟硬度及脂肪變定量檢測設備。

      目前《歐洲肝臟研究學會(EASL)臨床實踐指南》、《亞太地區(APASL)慢性乙型肝炎管理共識》、《中國慢性乙型肝炎防治指南》、《美國肝病學會(AASLD)肝細胞癌診療指南》、《中國脂肪性肝病診療規范化專家建議》等各類肝臟疾病診療指南已將其作為一項診療技術納入診斷標準。

           

      肝纖維化及脂肪肝定量檢測技術的優勢及特點?
            (1)無創無痛:無需肝穿刺活檢便能檢測出肝纖維化、脂肪肝程度,并可根據需要多次檢查。
            (2)快速簡便:全過程只需5分鐘,檢查結果立即顯示。
            (3)特異性強:專門為肝纖維化、脂肪肝的精準檢測量身定做的一款機器。
            (4)動態觀察:針對肝纖維化、脂肪肝程度顯示精確的數據,便于治療前后的療效觀察。
            (5)及早診斷:肝纖維化經過有效治療可以逆轉,進展為肝硬化時則無法逆轉,該檢測可實現肝纖維化的早診斷。
            (6)國際國內公認:是國際、國內廣泛認可的肝纖維化、脂肪肝無創檢測方法。
      哪些患者需要做肝纖維化及脂肪肝定量檢測?
            (1)各類肝病患者都適合做該項檢測,包括慢性乙型病毒性肝炎、慢性丙型病毒性肝炎、肝硬化、脂肪肝、自身免疫性肝病等。
            (2)抗病毒和抗纖維化療效動態評估的患者。
            (3)脂肪肝療效動態評估的患者。
            (4)肥胖尤其是腹型肥胖者。
            (5)想了解自身有無脂肪肝、肝纖維化及其程度的體檢人群。
      如何讀懂肝纖維化及脂肪肝定量檢測報告?

      CAP值反映肝臟的脂肪含量,正常參考范圍為100~238dB/m, CAP值>238 dB/m時,其數值越高,說明脂肪肝越嚴重:

      E值反映肝臟的硬度值,正常參考范圍為1.5~7.3 kPa,其臨床意義如下所示:

      注意事項:
            (1)應在空腹或餐后2小時進行。
            (2)有黃疸、腹水的患者不建議做,會影響結果的準確度。
            (3) 判斷肝臟硬度檢查結果時須結合患者的肝功能等綜合判斷。
            檢查時間:周一至周五全天,周六、周日上午。
            電話:0371--66211283 





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